Anti diabetic medicinal plants used for diabetes mellitus maryam rahimi department of horticultural science, university of zabol, iran abstract diabetes mellitus is a group of metabolic diseases characterized by high blood sugar glucose levels, that result from defects in insulin secretion, or action, or both. After acute toxicity test, the swiss albino mice were induced with alloxan to. Aegle marmelos, alloxan, antidiabetic, hyperglycemia. Rumex vesicarius showed a significant inhibitory action on. The phytoconstituents biomarkers present in aetpb were characterized by highperformance liquid chromatography hplc analysis. In vitro and in vivo antidiabetic effect of extracts of. Evaluation of antidiabetic activity of leaves and fruits. In vitro antidiabetic activity of caesalpina digyna r. Antidiabetic agents from medicinal plants bentham science. The plant metabolite montbretin a mba and its precursor minimba are potential new drugs for treating type 2 diabetes. Multiple, potentially antidiabetic plants were identi. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 gl. Many numbers of medicinal plant preparation and different formulations are available for the treatment of diabetes.
The bilberry plant has the following phytochemicals such as quercetin, catechins, tannins, vitamins and pectins 18. In vitro antidiabetic activity and mechanism of action of. The antidiabetic effects were found to be dosedependent. From the mass spectrum of dv 1, it was observed that a molecular ion peak at signal mz 304. Our goal is to metabolically engineer nicotiana benthamiana using montbretia genes to achieve increased production of mini. Ajuga remota, antidiabetic activity, blood glucose level, diabetes mellitus, glibenclamide, phytochemical screening.
Identification and quantification of bioactive compounds present was analysed by hplc. Hence, the chemical constituents of the plant extract might help in preventing diabetic complications and may serve as an alternative in the present armamentarium of antidiabetic drugs. Abutilon hirtum extract and fractions exhibited antiinflammatory analgesic, antipyretic and antipyretic activities which may be attributed by the. Antidiabetic activity medicinal plant aegle marmelos linn. Frontiers evaluation of antioxidant, antidiabetic and. In our study, the butanol fractions of selected plant species generally have been found more active than other fractions, indicating that compounds having antidiabetic activity are polar in nature which established the significant correlations of polyphenolic and flavonoids to lower down the. Antidiabetic activity of extracts and fraction of zizyphus. The extract, at a dose of 150, 300 and 450 mgkg body weight showed glucose reduction from 23. However, due to the potential toxicity of the plant extract it must be prescribed with caution. Petroleum ether, chloroform and aqueous extract of whole plant of cassia occidentalis were orally. Stzinduced diabetic mice showed significant p extract showed significant p activity of aqueous and methanol extract and fractions of gongronema latifolium leaves in alloxan diabetic rats p.
The inhibition varied from 49 to 68% in the concentration range of 250 to. Antidiabetic activity of vinca rosea extracts in alloxan. Chapter4 antidiabetic activity of the selected plants by in. Aloe vera is one of these antidiabetic plants grover, 2002. In vivo and in vitro antidiabetic activity of terminalia. Acute toxic class method is a stepwise procedure with use of three animals of a single sex per step. Determination of in vitro antidiabetic effects of zingiber. Today, more than 600 medicinal plants have been reported to have antidiabetic potential. An overview on antidiabetic medicinal plants having insulin. Antidiabetic studies on 50% ethanol extract, 90% ethanol extract and aqueous extract of coldenia procumbens was carried out using fasting glucose model, oral glucose tolerance test and streptozotocin induced diabetes model.
Materials and methods plant material zizyphus mauritiana was collected in march 2006 from tamil nadu, india. Perkin elmer vector 22 model ftir spectrophotometer nujol, 1h. In vitro and in vivo antidiabetic activity of rumex vesicarius leaves. Many herbs and plant products have been shown to have hypoglycemic action. Bhavani 1pg and research department of biochemistry, adhiparasakthi college of arts and science, kalavai 632506, vellore district, tn, india article info abstract article history.
Hence, the present study is planned to investigate the antioxidant and antidiabetic effects of methanolic extracts. Ethanolic extract of rumex vesicarius at 100, 200, 400 mgkg exhibited a dose dependent significant antidiabectic activity. The major aim of the study is to prove the hypoglycemic activity of a. Pdf antidiabetic effect of compounds isolated from plants. D i a b e tes o f t l a n r u o siol journal of diabetes and. Evaluation of the antidiabetic property of aqueous leaves. To investigate the antidiabetic effect of himalayan medicinal plants from india viz. In vitro investigation of antidiabetic potential of. The other 30 rats were injected with streptozotocin to induce diabetes by. Okolo rural dwellers in nigeria often resort to herbal remedy and dietary control in the treatment of diabetes mellitus dm. In vivo antidiabetic activity a marked rise in fasting blood glucose levels were observed in diabetic group when compared with normal control rats. The collected extract was stored at 04c until used. Chromolaena odorata is a medicinal plant whose root has not been reported for detailed antidiabetic properties. Pdf in vivo antidiabetic activity of the aqueous leaf.
The antioxidant and antidiabetic effects of its extracts are unclear. After 7 days the extract was filtered through muslin cloth and marc was discarded. Annona squamosa commonly called custard apple plant possesses antidiabetic activity. The rationale of the present study is to find out the level of efficacy and potency of the leaf extract in accordance with hypoglycemic activity. This study aims to examine the antioxidant and antidiabetic effects of 70% ethanolic extract of syzygium polyanthum wight leaf. Antidiabetic activities of chromolaena odorata methanol. To study and compare the effect of poly herbal plant extract phpe with glibenclamide gl on various parameters in streptozotocin stz induced diabetic rats. Most of these medicinal plants are scientifically validated for.
Phytochemical and in vitro antidiabetic activity of. The ethanolic extracts and the hexane and chloroform fractions of leaves and fruit peels showed promising antidiabetic activity in stzs model. Hence, this study investigated the antidiabetic properties of the methanol root extract of chromolaena odorata and its effect on biochemical parameters in alloxan induced diabetic rats. Evaluation antidiabetic activity of various leaf extracts of. Mimosaceae,also known as khair, is a medium sized deciduous tree with crooked and forked trunk. The in vitro antidiabetic activity of petroleum ether nonpolar and ethanol polar extracts were evaluated in c2c12 cell lines by 34,5dimethylthiazol2yl2,5diphenyltetrazolium bromide assay cell viability method and glucose uptake assay. Potential antidiabetic activity of extracts and isolated. Plant materialtrigonella foenumgraecum seed were chosen for the present study. This observed antidiabetic activity of this extract might be due to their phytochemical constituents previously reported. Mostly, this plant found europe and the northern usa forest 15,16. Pdf antidiabetic activity of 50% ethanolic extract of ricinus. The in vivo anti diabetic activity was screened in albino diabetic induced rats 7. Potential antidiabetic activity of medicinal plants a.
More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity 2635 examples of herbal medicines with proven anti diabetic activity plant part used. The selected plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using in vitro assays such as. Correlation analysis of total phenolics, antioxidant capacity, and antidiabetic activity. Animal models to test drugs with potential antidiabetic activity t. Antidiabetic herbal drugs and polyherbal formulation used for. The main objective of this work is to evaluate the in vitro anti diabetic activity of methanolic extracts of cinnamomum zeylanicum, piper betle, artocarpus heterophyllus and artocarpus altilis. Antidiabetic activity of alcoholic leaves extract of alangium lamarckii thwaites on streptozotocinnicotinamide induced type 2 diabetic rats. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. Aug 18, 2019 isolation, characterization and evaluation of anticonvulsant activity of rubus antidiabetic activity of the plant abutilon indicum in streptozotocin induced. Over 400 plants as well as 700 recipes and compounds have been scientifically evaluated for type 2 diabetes treatment.
By acute toxic class method swiss albino mice of female sex weighing 2025gms were used for the study. From the data obtained, it was found that methanol extract of s. Corresponding author qualitative analysis of plant materials for presenc in the present investigation, the ethanolic extracts of. Aqueous extract of leaves of 3 herbs murraya koenigii, mk. Preclinical evaluation of antidiabetic activity of poly herbal plant extract in streptozotocin induced diabetic rats p. In our study, the butanol fractions of selected plant species generally have been found more active than other fractions, indicating that compounds having antidiabetic activity are polar in nature which established the significant correlations of polyphenolic and flavonoids to lower down the diabetic effect. Journal of oen a c e biopharmaceutics and therapeutic. In vitro antidiabetic activity of ethanolic leaf extract of. Evaluation of the antidiabetic effect of trigonella foenum. In vitro antidiabetic activity of polar and nonpolar. The prevalence of diabetes mellitus dm is increasing with ageing of the population and life style changes associated with rapid urbanization and westernization. Antidiabetic activity of extracts from needle, bark, and.
The plant has been presented as a constituent of many. Solanaceae, a medicinal plant widely used in the traditional ayurveda and siddha systems of medicine for the treatment of. Antidiabetic activity of the compounds isolated from. An isolated fractions showing for higher anti diabetic activity was subjected to column chromatography that led to isolation of a pure compound, which was given trivial name lr1. Isolation and characterization of antidiabetic compound from dregeavolubils benth. Evaluation of antidiabetic activity of medicinal plant. Pharmacological and phytochemical appraisal of selected. Asian journal of plant science and research, 2011, 1 2. An isolated fractions showing for higher anti diabetic activity was subjected to column. The plant extract was pooled and evaporated to dry at 60c.
Plant polyphenols could modulate various enzymes and immune cells in the human body, apart from their antioxidant potential 33, 34. The antidiabetic activity of nigella sativa and propolis on. Antioxidant and antidiabetic activities of methanolic. The findings from this study therefore support the folkloric usage of b. Plants flavonoids with hypoglycemic activity continued. The methanolic extract at 500 mgkg dose level exhibited significant p activity. The fraction d from etlr was found to lower the fbg level significantly p of zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Materials and methods plant collection the leaves of the b. It also reduced hepatic and renal glucose6phosphatase and fructose 1, 6biphosphatase activity. First, we observed the antidiabetic activity of aqueous extract of the entire plant leaves, twigs and roots of a. Aloe vera aloe barbadensis known as secret plant originated from ancient egypt. The main objective of this work is to evaluate the in vitro anti diabetic activity of methanolic. The effect of the extract supported the traditional claim of the plant. Traditional medicines derived mainly from plants play major.
Evaluation of invitro antidiabetic and hypolipidaemic activities of extracts citrus lemon fruit 615 lemon fruit extract and standard acarbose against. Larvicidal activity of selected plant extracts against the. Pdf antidiabetic activity of water extract of solanum. These complex acylated flavonol glycosides only occur in small amounts in the corms of the ornamental plant montbretia crocosmia. Isolation and characterization of antidiabetic compound from. Antidiabetic activity of aqueous and methanol extract and fractions of gongronema latifolium leaves in alloxan diabetic rats p. Jul 14, 20 therefore, the present study was aimed to investigate in vivo antidiabetic activity of aqueous extract of terminalia paniculata bark aetpb in type 2 diabetic rats. There was a dosedependent increase in percentage inhibitory activity against alphaamylase enzyme. Anti diabetic medicinal plants open access journals.
Isolation and characterization of antidiabetic compound. Therefore the present study was carried out to investigate antidiabetic effect of m. A higher antiinflammatory activity was observed in extract obtained from microwave extraction 64. The observed fragmentation pattern shows that the similarity of a compound having an aromatic origin. Forty male albino rats were divided into four groups. D i a b e tes o f t l a n r u o siol journal of diabetes. Phytochemical screening and antidiabetic effect of. In vitro and in vivo antidiabetic effect of extracts of melia azedarach. Antioxidant activity was done by dpph diphenyl picrylhydrazyl assay method, meanwhile antidiabetic activity was done by in vivo studies using male rats wistar strain.
Morphological changes and hypoglycemic effects of annona. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of. Antilarvicidal activity of silver nanoparticles synthesized from sargassum polycystum against mosquito vectors. In the present study, we have evaluated terminalia chebula, terminalia belerica, emblica officinalis, their combination triphala for their antidiabetic activity and their relation with their antioxidant activity. The antidiabetic potential of the water extract of solanum trilobatum l. Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of the aqueous and 70% ethanol extracts on alloxaninduced diabetic mice. Cinnamomum cassia or chinese cinnamon is one of the fundamental herbs in traditional chinese medicine. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Some of potential herbal formulation such as hyponidd tablets, mersina capsules. Antidiabetic activity of ethanolic extract of hydnocarpus. Evaluation antidiabetic activity ijppr, volume 7, issue 3, june 2015 july 2015 page 600 table 3. Antidiabetic activity of alcoholic extract of neem.
Antidiabetic and thrombolytic effects of ethanolic extract of. Comparative study of in vitro antioxidant and antidiabetic activity of plant extracts of acacia arabica murraya koeingii catharanthus. Herbal plant fenugreek used for antidiabetic aloe vera and aloe barbadensis. Blume was selected which was traditionally used for various ailments like leprosy, antioxidant, secondary syphilis, rheumatism ophthalmic, the folklore claim of hydnocarpus wightiana blume shows that it is having antioxidant properties and antidiabetic activity. The plant extract showed significant hypoglycemic and antihyperglycemic effect in normoglycemic and diabetic mice. All solvents were distilled off prior use for extraction and fractionation process.
Thus, these data imply that the butanol fraction of a. Medeirosb a department of clinical analysis, center of health sciences, federal university of santa catarina, campus universit. Alphaamylase inhibitory activity alpha amylase ec 3. Introduction diabetes mellitus is the one of the challenging health. Evaluation of in vitro anti diabetic activity of selected. Chatree, botanist, government arts and science college, mandsaur, india. Preclinical evaluation of antidiabetic activity of poly. Nair1, vaibhavi kavrekar1, anshu mishra1 1 department of biotechnology, mount carmel college, bangalore, karnataka, india abstract.
Antidiabetic and antioxidant activities of roylea cinerea. Antidiabetic activity of the compounds isolated from rhus mysorensis plant extract doi. Models to study in vitro antidiabetic activity of plants. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocininduced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity. This study was conducted to compare the ameliorative effect of nigella sativa and propolis methanol extract on streptozotocin induced diabetic male rats and treating diabetic nephropathy. Asparagus racemosus liliaceae the ethanol extract, hexane, chloroform and ethyl acetate. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin.
Wagh 1, manoj mohan 2 and at shivashanmugam 2 1ibss college of pharmacy, malkapur ms 2srips cop, coimbatore. The aqueous ethanol and butanol extracts have shown significant reduction in blood glucose levels in both glucose loaded and alloxan induced diabetic rats. However, due to the potential toxicity of the plant extract. More than 800 plant species are reported as antidiabetic. The current form of herbal medicine has historical roots in medieval grecoarab, ancient egyptians, chinese, and other ancient medicines. This extract was used for in vitro and in vivo analysis of antidiabetic activity. Different types of extracts from different part of plant were used for different activities e. Psidium guajava, pg and catharanthus roseus, cr were used to test their antidiabetic activity in streptozotocin stz induced diabetic albino rats.
Arika wm, abdirahman y a, mawia ma, wambua kf, nyamai dm, et al. Possible therapeutic potential for diabetic complications curr diabetes rev 2012. Antidiabetic activity of terminalia catappa leaf extracts ijpt. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Evaluation of in vitro anti diabetic activity of selected plant extracts sindhu. Antidiabetic and antihyperlipidemic activities of the leaf.
Physalis minima is widely used in indian medicine by the tribal communities to treat. Invitro and invivo studies of antidiabetic activity of. Determination of in vitro antidiabetic effects of zingiber officinale roscoe 603 glucose diffusion inhibition the potential of ginger rhizome extracts to inhibit glucose diffusion into the external solution was investi gated at set time intervals gallagher et al. Ethanol extract of this plant is reported to reduce. It was extracted up to one week with daily 2 hours stirring with a mechanical stirrer.
The percentage inhibition at 19 mgml concentrations of rumex vesicarius leaf extract showed a concentration dependent increase in the percentage inhibition. It acts by promoting insulin release from the pancreatic islets, increasing utilization of glucose in muscle and inhibiting the glucose output from liver 9. Antidiabetic activity of cassia occidentalis linn in normal and. Introduction in folk medicinal practice many plants are used to treat diabetes mellitus in south india. Further study to substantiate the use of the plant as antidiabetic is recommended. The antidiabetic activity in plants may be attributed to the presence of phenolic and flavonoid compounds. Antidiabetic activity of some herbal plants in streptozotocin. The plant was subjected to pharmacognostic, physicochemical and phytochemical evaluations which will assist in standardization for authenticity. Antidiabetic activity medicinal plant aegle marmelos. The taxonomical identification of the plant was done by h. Evaluation of antidiabetic potential of whole plant extracts. Antidiabetic and antioxidant activities of roylea cinerea extracts 6 determination of total phenolic content where a the total phenolic content of the extracts of r. Ajuga remota benth is traditionally used in ethiopia for the management of diabetes mellitus.
Pharmacological screening assay of experimental animal after oral administration. Foeniculum vulgare, antidiabetic activity, aqueous extract, streptozotocininduced diabetic rats. Antidiabetic activity and phytochemical screening of. The most widely known effect of gymnema sylvestre is anti diabetic activity. Larvicidal activity of selected plant extracts against the dengue vector aedes aegypti mosquito pedro m.
Role of plant antioxidants in diabetes has not been undertaken. In vitro investigation of antidiabetic potential of selected. The scientific articles evidenced that the fruit has antidiabetic and hypoglycemic activity 17. Screening for antidiabetic activity of the ethanolic extract of. To evaluate the hypoglycemic activity of various extracts. Mar 21, 2020 there exists a genetic predisposition to diabetes. In the stzinduced diabetic mice, both extracts showed a strong antihyperglycemic activity, with the group receiving 50 mgkg of ethanol extract and the group receiving 50 mgkg of aqueous extract presenting 64. Preparation of plant extracthundred gram of dry powdered oft.
518 801 1587 1426 1599 311 378 1083 463 694 1510 1348 1476 1414 197 379 502 167 1668 951 973 1252 1180 856 158 797 1005 1173 409 288 880 665 19 654 1358 1313